Over a two-year period, the trial demonstrated a 42% reduction in new sexually transmitted HIV infection in the intervention communities compared with the control communities. This study provides strong evidence of the impact of improved treatment of symptomatic STIs.
A study conducted recently in
These results suggest that urethritis increases the infectiousness of men with HIV-1 infection and that programmes which include detection and treatment of STDs in patients already infected with HIV-1 may help to curb the HIV epidemic.
- 10 fold increased risk of HIV transmission in presence of Ulcerative STIs
- Ulcerative STIs results in breaks in genital tract lining or skin and create a portal of entry for HIV. Micro erosions caused by STIs also facilitate HIV entry.
- Both Ulcerative & Non ulcerative STIs & RTIs increase the concentration of T-cells in the genital secretions and genital linings that can serve as target of HIV.
- HIV positive individuals who are also infected by STIs have shown increased concentration of HIV (viral load) in the genital lesions.
- Both ulcerative & Non Ulcerative STIs and RTI increase HIV shedding in the genital secretions of HIV positive individual. Bleeding from the genital ulcer is another contributory factor.
- There is mounting evidence that some STI pathogens become more virulent in presence of HIV related immune deficiency.